Overview

Selling chemical-based products on Amazon comes with a significant set of regulatory and platform-specific requirements that every seller must understand. From safety data sheets to labeling rules and restricted substances, Amazon enforces strict compliance standards to ensure customer safety. Sellers who fail to meet these requirements risk listing removal, inventory disposal, and potential customs issues for international shipments.

Key Points / What Sellers Need to Know

• Safety Data Sheets (SDS) are mandatory — Every chemical-based product listed on Amazon must have a current, accurate safety data sheet on file. This is non-negotiable for regulated products.
• Professional-use chemicals are prohibited — Amazon does not allow the sale of chemicals designated for professional use only. Inventory identified as professional-use at fulfillment centers may be disposed of at the seller's expense.
• Proper labeling is required — All regulated chemical products must display appropriate hazard statements, precautionary statements, pictograms, and supplier contact information in the language of the marketplace.
• Bundles and kits need multiple SDS documents — If your listing includes a bundle or kit containing more than one chemical-based product, you must submit a separate SDS for each individual product.
• Non-compliance has serious consequences — Listings can be removed, FBA inventory can be destroyed without compensation, and internationally shipped products may be seized at customs.

Regulatory Framework

Several major U.S. federal regulations govern the sale of chemical products, and Amazon sellers are expected to comply with all of them. The Toxic Substances Control Act (TSCA) covers chemical substances manufactured in or imported into the United States, including articles that contain hazardous chemicals. The Occupational Safety and Health Administration (OSHA) sets workplace chemical safety standards that also affect product handling and documentation. The Federal Hazardous Substances Act (FHSA) and the Consumer Product Safety Act (CPSA) add further layers of consumer protection requirements. Sellers must also be aware of the Globally Harmonized System (GHS) standards, which dictate labeling conventions and packaging rules for hazardous materials.