Overview

Error 100459 appears when a dietary‑supplement listing does not satisfy Amazon’s safety and regulatory standards. The block prevents the product from becoming active on the marketplace until the seller supplies the required documentation, removes prohibited health claims, and verifies that all ingredients are allowed. Resolving the error quickly is critical for sellers who rely on supplement sales to maintain revenue and account health.

Key Points

• Compliance‑driven block — Amazon disables any supplement listing that fails to meet the platform’s category‑specific safety rules, stopping the item from appearing in search results.
• Missing safety documents — Listings lacking a Certificate of Analysis, third‑party testing results, or other mandated certifications trigger the error, as Amazon cannot verify product safety.
• Unapproved health claims — Any statement that suggests disease treatment, cure, or performance enhancement—such as “boosts immunity 100 %” or “eliminates joint pain”—will be flagged for violating FDA and Amazon policy.
• Prohibited ingredients — Products containing ingredients on Amazon’s restricted list (e.g., ephedra, certain high‑dose vitamins, or unapproved botanical extracts) are automatically blocked, even if the ingredient is legal under federal law.
• Multiple compliance layers — Fixing the error requires addressing documentation, ingredient eligibility, and claim language simultaneously; correcting only one element rarely lifts the block.
• Review‑queue delay — After resubmission, Amazon’s compliance team may need several business days to re‑evaluate the listing, extending the downtime for the product.

How to Resolve Error 100459

1. Download the policy checklist — Access the “Dietary Supplement Compliance Checklist” in Seller Central and compare each requirement to your current listing; for example, note whether the supplement facts panel includes a complete ingredient breakdown.
2. Gather required certificates — Upload a recent Certificate of Analysis, third‑party lab test results, and any applicable GMP (Good Manufacturing Practice) certifications; a seller of a probiotic capsule might attach a lab report showing CFU counts and strain verification.